LUPUS ERYTHEMATOSUS PROFUNDUS

Also known as lupus panniculitis, lupus erythematosus profundus (LP, LEP) is an unusual variant of cutaneous lupus erythematosus that is characterized by chronic, recurrent inflammation of the underlying fat leading to nodules, lipoatrophy and significant depression.

Deep-seated inflammatory nodules, induration and/or lipoatrophy caused by lupus of the fat.
The average age at onset in one review was 36 years and 85% were women. 21% had coexistent SLE, 28% DLE and 13% had both.

Clinical

Lipoatrophy, deep subcutaneous nodules, and/or morphea-like lesions may occur most commonly on the upper arm, breasts, thighs, buttocks, face and back. The overlying skin may be normal or show DLE lesions.

DLE-like lesions may be seen on the surface.

Here, a punched-out ulcer.

The thigh is another typical location.

Reticultated, livedo pattern of erythema with necrosis and ulceration.

RegionalDerm

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