A single longitudinal melanonychia.
LONGITUDINAL MELANONYCHIA
Longitudinal Melanonychia (LM) is a longitudinal pigmented streak of the nail caused by melanin in the nail plate.
- LM is caused by either
- Activation of melanocytes (normal number of melanocytes but increased activity).
- Proliferation of melanocytes (an increased number of melanocytes)--two types, benign and malignant.
- When multiple nails are affected the cause is melanocytic activation.
- 6% of single LM in adults are melanoma.
- Be very suspicious of LM of the thumb or great toe in a patient > 50 years of age.
Causes of LM by Activation
Causes of LM by Proliferation
- Nevus
- Blue nevus
- Lentigo
- Atypical lentiginous melanocytic hyperplasia/Nevus with atypia
- Melanoma in situ/Melanoma (subungual melanoma)
Causes of Dark Streaks of the Nail That Are Not LM
- Onychomycosis
- Onychocytic Matricoma
- Onychomatricoma
- Onychopapilloma
Clinical
A longitudinal brown streak of the nail is seen. The origin is the base of the nail (proximal nail fold) and the width of the pigmentation is uniform. (Rarely, with rapidly growing lesions, the width may be progressively wider proximally, giving what is called the "triangular sign".) This reliable and distinct pattern helps distinguish LM from subungual hematoma or darkening from onychomycosis. Those patterns of darkening are random, haphazard and often not contiguous with the proximal nail fold.
Pigmentation of the proximal or lateral nail folds, and hyponychium (Hutchinson's sign) can be a sign of melanoma but is not uncommon in benign LM, especially in children. Complete darkening of the nail is called total melanonychia.
Nail clipping with special stains can be used to confirm that the pigment is melanin.
Additional Photographs
Multiple LM.
A more worrisome LM as it is wider and with multiple shades.
Biopsy of the base of a new dark LM. Biopsy showed melanoma in situ.
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A single longitudinal melanonychia.
