Erythematous, scaly plaques, some with annular forms.
SUBACUTE CUTANEOUS LUPUS ERYTHEMATOSUS
Subacute Cutaneous Lupus (SCLE) is a variant of lupus in which SSA (Ro) and SSB (La) antibodies are positive. It tends to occur in older woman, preferentially affects the trunk, and tends to have a papulosquamous morphology.
- Drug-induced SCLE occurs.
- Bacteria in the human microbiome may be triggers of lupus. Bacteria containing Ro orthologs have been found in lupus patients. CD4 memory cells from lupus patients are stimulated by Ro-containing bacteria.
Red, scaly, annular lesions, often on the upper trunk of a middle-aged woman, is typical. Lesions may appear as and be misdiagnosed as psoriasis.
Drug-Related
Various drugs have been reported to induce SCLE. The most compelling include terbinafine, hydrochlorothiazide and proton pump inhibitors, e.g. omeprazole.
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