A 6-month-old child presented with this firm yellow nodule on the upper thigh. No CALMs nor other cutaneous findings were present. The parents were told these lesions usually spontaneously involute over 1-2 years without a scar.

JUVENILE XANTHOGRANULOMA

The juvenile xanthogranuloma (JXG) is a benign, generally asymptomatic proliferation of non-Langerhans histiocytic cells. It usually presents as a yellowish papulonodule in a child.

Juvenile xanthogranuloma typically presents as a solitary lesion in a young child usually under 1 year of age, but it can be congenital and multiple lesions may occur. It is most common on the head and neck.

Systemic

Rarely, JXG may occur in extracutanous locations. In one meta-review, the incidence of systemic manifestations was 0.75% (22/2949) and of ocular manifestations 0.24% (7/2949).


Multiple CALM in a child with neurofibromatosis and JXGs.


Juvenile xanthogranulomas) are relatively common in children 2 years and younger with neurofibromatosis.

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