A 14 year-old-boy with multiple dermal blue nodules, disseminated in different segments of the body. The patient's family history was positive for similar lesions; his mother and maternal grandmother had some asymptomatic blue nodules on their body.
GLOMANGIOMA
A glomangioma is a congenital, benign, vascular neoplasm caused by mutations in glomulin gene, with an autosomal dominant pattern of inheritance.
- Multiple glomus tumors may develop in childhood, adolescence, or adulthood.
- It is similar to venous malformations clinically.
- Histologically, it is deficient in smooth muscle and abundant in glomus cells.
- Glomus cells are normally found in the glomus body, an arteriovenous shunt.
- Glomangiomas are commonly familial (whereas venous malformations are rarely inherited).
Multiple glomus tumors may develop in childhood, adolescence, or adulthood. These tumors may be multilobular or plaque-like and may have a vascular, cobblestone, or hyperkeratotic surface. They are not easily compressed and compression may aggravate the associated pain. They are most common on the extremities and may be segmental in distribution.
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