Velvety thickening of the skin on the nape.
ACANTHOSIS NIGRICANS
Acanthosis Nigricans (AN) is a velvety thickening of the skin of the neck and axilla.
- It is a marker for insulin resistance, elevated serum insulin levels, and future risk of diabetes.
- It often runs in families.
- Chronic insulin injections at one site can induce AN locally.
Clinical
Acanthosis nigricans presents as a thickening of the skin. Velvety thickening of the skin occurs on the neck and axilla. The elbows and of the hands may be involved as well. In the case of insulin resistance, the patient is usually obese. Diabetic finger pebbles is a variant that occurs on the knuckles. Acanthosis nigricans is more common in young adults and non-whites.
AN at the site of insulin injections.
AN at the site of insulin injections.
AN on the side of the neck.
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