By Gary M. White, MD

Eruptive Xanthomas Innumerable eruptive yellow papules.

Eruptive xanthomas are diffuse, multiple xanthomas deposited in the skin from acute elevation in blood triglycerides. Conditions which predispose to this eruption include diabetes mellitus, chronic renal failure, nephrotic syndrome, hypothyroidism, alcohol ingestion, underlying hypertriglyceridemia and certain drugs (e.g., isotretinoin).


A widespread, symmetric eruption of yellow papules with preference for the knees, elbows, and buttocks occurs in eruptive xanthomas. Patients should be evaluated for pancreatitis as the hypertriglyceridemia can induce this as well.


The cutaneous eruption resolves within weeks, once the hypertriglyceridemia is corrected.

Additional Pictures

Courtesy Michael O. Murphy, MD
Eruptive Xanthomas

Eruptive Xanthomas


Dermatol. Argent., 2015, 21 (3): 213-216


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