WHITE SPONGE NEVUS
By Gary M. White, MD
Note the Fordyce spots on the upper lip as well.
The white sponge nevus (WSN) is akin to an epidermal nevus, but located on the mucosa.
- A similar lesion may be seen in dyskeratosis congenita.
- In two families, mutation of the gene that encodes keratin 4 was found [Nature Gen 1995;11;450-5].
A white, spongy, hyperkeratotic plaque is seen on the mucosa, usually the oral mucosa, but the vulvar or perianal mucosa may be affected as well. Onset is in childhood. Some familial cases have shown AD inheritance [J Eur Acad Derm Vener 1995;4;283]. Women are more commonly affected than men by a ratio of 3:1.
No reliable therapy exists. Reassurance is all that is usually done.
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