WERNER SYNDROME

By Gary M. White, MD


Werner Syndrome is a premature aging condition, also known as pangeria or adult progeria, and is inherited AR.

Clinical

Clinical findings include short stature, premature graying of hair, premature baldness, poikilodermatous skin, trophic ulcers of the legs, cataracts, hypogonadism, tendency to diabetes, calcification of blood vessels, osteoporosis, metastatic calcification, a high-pitched voice, increased incidence of neoplasia, flat feet, hyperreflexia, and irregular dental development.

Treatment

Referral to a specialist familiar with this syndrome is in order. The leg ulcers have been treated with bosentan [JAAD 2011;65, Issue 2, Pages e54–e55].

References

Leg ulcers. JAAD 2011;65, Issue 2, Pages e54–e55

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