By Gary M. White, MD
Werner Syndrome is a premature aging condition, also known as pangeria or adult progeria, and is inherited AR.
- It is caused by dysfunction of the DNA helicase encoded by WRN, the gene responsible for WS.
Clinical findings include short stature, premature graying of hair, premature baldness, poikilodermatous skin, trophic ulcers of the legs, cataracts, hypogonadism, tendency to diabetes, calcification of blood vessels, osteoporosis, metastatic calcification, a high-pitched voice, increased incidence of neoplasia, flat feet, hyperreflexia, and irregular dental development.
Referral to a specialist familiar with this syndrome is in order. The leg ulcers have been treated with bosentan [JAAD 2011;65, Issue 2, Pages e54–e55].
Leg ulcers. JAAD 2011;65, Issue 2, Pages e54–e55
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