WEBER-COCKAYNE VARIANT OF EPIDERMOLYSIS BULLOSA SIMPLEX
By Gary M. White, MD
Weber-Cockayne EB is a mild variant of epidermolysis bullosa simplex which causes blistering of the palms and soles.
- It is caused by a dominant-negative mutation in either KRT5 or KRT14, the genes encoding keratin 5 and keratin 14 proteins, respectively.
- Genetic counseling is in order.
A 5-year-old boy presented with blisters and erosions on the palms and soles since infancy. They resulted from minimal mechanical trauma. Ann Dermatol. 2014 Dec; 26(6): 739–742
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