VOGT-KOYANAGI-HARADA SYNDROME

By Gary M. White, MD


Vogt-Koyanagi-Harada Syndrome (VKHS) is the combination of alopecia, poliosis or vitiligo along with ocular disease and neurologic problems.

Clinical

Vitiligo unilaterally along with poliosis of the eyelashes and/or eyebrows is seen. Alopecia areata may be associated [JAAD 1992;26;496]. A prodromal generalized erythroderma has been noted [Dermatology 1999;198;65].

Diagnosis

Criteria for diagnosing Vogt-Koyanagi-Harada (VKH) Syndrome were adopted in 1978 by the American Uveitis Society. They are 1) no history of ocular trauma or surgery and 2) at least 3 of the 4 following signs:

Treatment

Treatment of individual problems should be carried out by both a dermatologist and ophthalmologist. For vitiligo lesions, topical tacrolimus and clobetasol can be beneficial, as with typical vitiligo [PD 2017;34;204].

References

University of Iowa

A 14-year-old boy presented with 3 months of depigmented macules and patches on the face, hands and scrotum. One hear before, he had experienced rapid onset of headaches, nausea, vomiting, bilateral eye pain and blurry vision. Panuveitis and bullous serous retinal detachments were found [PD 2017;34;204].

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