By Gary M. White, MD

Erythema and/or hyperpigmentation of the skin overlying a vein may occur after intravenous administration of a chemotherapeutic agent, e.g. 5-fluorouracil, docetaxel [BJD 2000;142;1069].


Linear erythema and/or hyperpigmentation occurs over the vein in which the drug was administered. There need not have been extravasation, thrombosis or phlebitis.


No treatment is needed. The abnormal coloration usually resolves over time.


Indian J Dermatol Venereol Leprol 2010;76:714-5


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