TRICHODYSPLASIA SPINULOSA

By Gary M. White, MD


Trichodysplasia spinulosa (TS) is a viral infection produces multiple tiny follicular spicules in immunosuppressed patients. Patients typically have solid organ transplantation, acute or chronic leukemia, non-Hodgkin’s lymphoma, or multiple myeloma.

Clinical

Innumerable, tiny follicular spines develop in the face and then proceed to the trunk and extremities. Alopecia of the eyebrows and eyelashes is typical. One patient with Gorlin syndrome had TS precipitated by treatment with vismodegib (Erivedge). Stopping the vismodegib led to resolution and rechallenge resulted in recurrence [JAMA Derm 2014;150;1016].

Treatment

Restoring normal immune function can lead to complete remission. Both valaciclovir and valganciclovir have cleared the eruption in isolated reports.

References

Acta Dermato-Venereologica

Pediatric Dermatology 1015;32;545

RegionalDerm

Homepage | FAQs | Use of Images | Contact Dr. White


It is not the intention of RegionalDerm.com to provide specific medical advice, diagnosis or treatment. RegionalDerm.com only intends to provide users with information regarding various medical conditions for educational purposes and will not provide specific medical advice. Information on RegionalDerm.com is not intended as a substitute for seeking medical treatment and you should always seek the advice of a qualified healthcare provider for diagnosis and for answers to your individual questions. Information contained on RegionalDerm.com should never cause you to disregard professional medical advice or delay seeking treatment. If you live in the United States and believe you are having a medical emergency call 911 immediately.