By Gary M. White, MD

Syringomatous adenoma Of The nipple (SAN) is a benign, but locally aggressive tumor of the breast and nipple.


SAN typically presents as a 1-3 cm nodule or mass in the nipple or subareolar region. Mammography often suggests malignancy. Diagnosis is confirmed by biopsy.


Surgical excision with clear margins is in order. Positive margins usually lead to recurrence.


A 41-year-old Japanese woman presented with firmness of her right nipple and abnormal nipple discharge [J Med Case Rep. 2015; 9: 256]


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