SUBUNGUAL SQUAMOUS CELL CARCINOMA

This lesion, partially hidden under the nail, had been present and slowly growing for 10 years.
Subungual squamous cell carcinoma

Rarely, squamous cell carcinoma (SCC) may occur in the periungual/subungual area. See also squamous cell carcinoma. HPV has been found in up to 80% of lesions and it has been theorized that these lesions in fact may have been verruca for many years and only subsequently underwent malignant change. HPV 16 is most common.

Clinical

A hyperkeratotic or verrucous, periungual, or subungual lesion treated for years as a verruca is characteristic. Pain, swelling, inflammation, redness, bleeding, and nail deformation are common. Men 50-80 years of age and a single finger are most typical.

Treatment

Some have recommended amputation, however, these SCCs tend to be less aggressive and most recommended Mohs surgery. Radiation therapy is a good alternative for patients who are poor surgical candidates.

Additional Pictures

Subungual squamous cell carcinoma

References

JAAD August 2013 Volume 69, Issue 2, Pages 253–261.e1

SCC Periungual from JAAD September 2014 Volume 71, Issue 3, Pages e65–e67

RegionalDerm

Homepage | FAQs | Contact Dr. White


It is not the intention of RegionalDerm.com to provide specific medical advice, diagnosis or treatment. RegionalDerm.com only intends to provide users with information regarding various medical conditions for educational purposes and will not provide specific medical advice. Information on RegionalDerm.com is not intended as a substitute for seeking medical treatment and you should always seek the advice of a qualified healthcare provider for diagnosis and for answers to your individual questions. Information contained on RegionalDerm.com should never cause you to disregard professional medical advice or delay seeking treatment. If you live in the United States and believe you are having a medical emergency call 911 immediately.