Note: This is a summary only. Please consult the latest information when prescribing.
- Topical ivermectin 1% cream (Soolantra) once daily is approved in the US for the treatment of rosacea.
- Its vehicle is very similar to Cetaphil moisturizing cream.
- Soolantra has fewer adverse events than its vehicle!
- Soolantra is more effective than metro gel 0.75% cream for rosacea and probably more effective than azalea acid.
Indications And Usage
SOOLANTRA cream is indicated for the treatment of inflammatory lesions of rosacea.
Dosage And Administration
1% ivemectin cream. Apply once daily
Apply to the affected areas of the face once daily. Use a pea-size amount for each area of the face (forehead, chin, nose, each cheek) that is affected. Spread as a thin layer, avoiding the
eyes and lips.
- Side effects were actually less in the ivermectin group than the placebo group.
- Adverse reactions, reported in ≤ 1% of subjects treated with SOOLANTRA cream for at least 3 months in vehicle-controlled clinical trials, included skin burning sensation and skin irritation.
Pregnancy Category C.
In two pivotal studies, the number of patients who were clear or almost clear at 12 weeks was 38%-40% for ivermectin vs. 12%-19% placebo [J Drugs Dermatol. 2014 Mar;13(3):316-23].
Ivermectin is clearly more effective than topical metronizadole cream 0.75% [Br J Dermatol. 2014 Sep 16]. Evidence also suggests topical ivermectin once a day is more effective than topical azalea acid BID.
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