By Gary M. White, MD

Shagreeen patch

The shagreen patch (SP) is a connective tissue nevus or collagenoma that occurs in the lumbosacral region and is a marker for tuberous sclerosis.


An irregular, elevated, flesh-colored plaque located in the lumbosacral region is characteristic. The surface is characteristically skin colored and leathery with prominent follicular openings resembling an orange peel (peau d'orange). Occasionally, tuberous sclerosis complex-related connective tissue nevi may occur elsewhere, e.g. the central or upper back, buttocks or thighs. Elastic fibers are typically decreased [JAMA Derm 2017;153;660].


Indian J Dermatol Venereol Leprol 2015;81:23-8


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