By Gary M. White, MD
- Docetaxel and paclitaxel are taxanes that are widely used in the treatment of various malignant neoplasms.
- A scleroderma-like skin change is a rare but important potential side effect of taxanes.
- Some have suggested 3 stages:
(ii) edema and sclerosis
- Versican is a large chondroitin sulfate proteoglycan and intense versican deposits have been documented in lesional skin [British Journal of Dermatology 2015;173;1054–1058].
There may be acute or gradual onset of nonpitting edema in selected areas of the body. The extremities are commonly affected.
It should be noted that taxanes can cause a wide variety of cutaneous eruptions including exanthems, purpuric papules, photodistributed eruptions, violaceous annular lesions, erythematous to violaceous macules with hemorrhagic centers, acral erythema, Stevens-Johnson, hemorrhagic vesicles, and follicular-based papules and pustules [JEADV 2016;30;638].
British Journal of Dermatology 2015;173;1054–1058
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