By Gary M. White, MD

Rhinoscleroma is an infection predominately of the nasal mucosa caused by Klebsiella rhinoscleromatous.


An enlarged, crusted, deformed nose occurs is typical. Nodules or ulcerating plaques may be seen intramurally as well.


Tetracycline is the drug of choice. Other antibiotics including ciprofloxacin, rifampicin, cephalosporins, and trimethoprim-sulfamethoxazole. The antibiotics should be continued for several months (3–6 months) until the biopsy and culture results are negative.


A 39 year-old man who had lived his entire life in rural Colombia presented with a history of five years of a growing painful mass on his left nostril, which caused airway obstruction. A six-month regimen of ciprofloxacin (750 mg every 12 hours) was started, and the patient showed dramatic improvement. Am J Trop Med Hyg. 2015 Jan 7; 92(1): 3


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Rhinoscleroma is a chronic, slowly progressive granulomatous bacterial infection that is endemic to the tropical world, namely, Central America and Africa. It is occasionally seen in the United States of America (USA). It The well-known causative agent for rhinoscleroma is the bacterium Klebsiella rhinoscleromatis, a subspecies of Klebsiella pneumoniae. However, Klebsiella ozaenae can also, albeit very rarely, cause rhinoscleroma