Raynaud's phenomenon in a patient with CREST syndrome.
Raynaud's phenomenon

Raynaud's phenomenon is the transient blanching followed by hyperemia of a digit. It commonly is associated with various collagen vascular diseases.


Sharply-demarcated blanching occurs initially, followed by cyanosis and subsequently hyperemia in Raynaud's phenomenon. One or multiple fingers may be affected. Prolonged vasospasm may cause digital necrosis. Precipitating factors include cold exposure, mental stress, drugs, and certain occupations. Trophic changes may occur after chronic involvement. Underlying diseases include collagen vascular (e.g., systemic sclerosis, SLE), drugs (e.g., beta blockers), and arterial disease (e.g., thromboangiitis obliterans). When idiopathic, the term Raynaud's disease is used.


Precipitating factors should be avoided. Smokers should quit. Nifedipine may be prescribed. IV calcitonin gene-related peptide is being investigated for the patient with severe disease.


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