LIPS

By Gary M. White, MD

Cheilitis

Actinic Cheilitis. Just the lower lip is involved in contrast to allergic contact dermatitis.
Actinic Cheilitis

Allergic contact dermatitis (ACD) as shown here to lipstick. The majority of patients with ACD of the lips are women and the most common offender is lipstick. Both lips are typically involved. Always consider ACD to lip balms, facial cosmetics, toothpaste and other oral products, artificial nails, things held in mouth (e.g. metal tool, paperclip), and black hair dye for mustaches. Rarely, consider a consort dermatitis (girlfriend's lip products) causing lip dermatitis. Food may cause ACD of the lips, e.g. eating mangoes. When patch testing is done, nickel and fragrance are the most common offenders.
Allergic Contact Dermatitis to Lipstick

Irritant Contact Dermatitis

Atopic Dermatitis

Isotretinoin Cheilitis. Everyone treated with isotretinoin gets dry, chapped lips.
Isotretinoin Cheilitis

Vitamin Deficiency. Deficiency of several vitamins has been known to cause cheilitis. They include deficiency of zinc, vitamin B2 (riboflavin), vitamin B12 and biotin. Excess of vitamin A may also cause cheilitis.

Rarely, food allergy may cause swollen lips.

Factitial cheilitis may rarely occur.

Actinic Prurigo

Crusted/Inflamed/Erosive

Herpes Labialis
Herpes Labialis

Mycoplasma Pneumoniae-induced Rash and Mucositis

Erythema Multiforme

Stevens-Johnson Syndrome

Herpetic Gingivostomatitis
Herpetic Gingivostomatitis

DRESS Syndrome

Toxic Epidermal Necrolysis
Toxic Epidermal Necrolysis

Pemphigus Vulgaris PV may present just on the lower lip. For a picture, see Case Reports in Dermatological Medicine Volume 2014 (2014), Article ID 147197,

Cleft

Cleft lip may occur along with other congenital malformations and in conjunction with various rare cutaneous disorders, e.g., AEC syndrome. A blue macule may rarely be associated, usually in a Japanese child, especially when the cleft goes beyond the vermilion border [JAAD 1994;30].

Cyst

Mucocele
Mucocele

Enlargement

Angioedema, in this case from the sun, so called solar angioedema.
Solar Angioedema

Angioedema, Hereditary

Ascher Syndrome For a picture, see DermatologicaSinica March 2015;33, Issue 1, Pages 26–28.

Congenital Double Lip For a picture, see Eur J Gen Dent 2014;3:199-201.

Cheilitis Glandularis
Cheilitis Glandularis

Food Allergy: Allergies to food can rarely cause swelling of the lips.

Orofacial Granulomatosis and Melkersson-Rosenthal Syndrome (photo courtesy Michael O. Murphy, MD)
Orofacial Granulomatosis and Melkersson-Rosenthal Syndrome of the Lips

Reaction to injection of filler substance.
Reaction to Injection of Filler Substance in the Lips

Fissure

Fissured Lip For a picture, see Wikipedia

Growth/Tumor

Squamous Cell Carcinoma
Squamous Cell Carcinoma of the Lip

Mutilated

Cancrum Oris For a picture, see Virtual Grand Rounds in Dermatology

Lesch-Nyhan Syndrome: Self-mutilation may occur in Lesh-Nyan Syndrome.

Espundia

Papules/Nodules

Fibroma
Fibroma

Multiple Mucosal Neuroma Syndrome For a picture, see WeCareIndia

Perleche

Angular Cheilitis
Angular Cheilitis

Riboflavin Deficiency

Pigmented

Laugier-Hunziker Syndrome
Laugier-Hunziker Syndrome

Labial Melanotic Macule
Labial Melanotic Macule

Peutz-Jeghers Syndrome
Peutz-Jeghers Syndrome

Carney Complex
Melanoma For a picture, see JAAD April 2014 Volume 70, Issue 4, Pages 748–762 or Dermatology Online Journal 14(8)

Minocycline Melanosis
Minocycline Melanosis

Oral Melanoacanthoma. A rapidly growing solitary brown patch on the oral mucosa [Jama Derm May 2014 150:563]

Physiologic Pigmentation

Postinflammatory Hyperpigmentation This pigmented lesion of several months was biopsy proven to by postinflamatory hyperpigmentation.
Postinflammatory Hyperpigmentation

Inherited Patterned Lentiginosis in Blacks
Inherited Patterned Lentiginosis in Blacks

Drug-Induced

Pits

Lip Pits

Telangiectasias

Hereditary Hemorrhagic Telangiectasia

Scleroderma
Scleroderma

Vascular

Pyogenic Granuloma
Pyogenic Granuloma

Venous Lake Venous Lake of the Lip

Vesicles

Herpes Simplex
Herpes Simplex of the Lip

White

Leukoplakia in Actinic Cheilitis
Leukoplakia in Actinic Cheilitis

Yellow

Fordyce Spots
Fordyce Spots

RegionalDerm

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