By Gary M. White, MD
Actinic Cheilitis. Just the lower lip is involved in contrast to allergic contact dermatitis.
Allergic contact dermatitis (ACD) as shown here to lipstick. The majority of patients with ACD of the lips are women and the most common offender is lipstick. Both lips are typically involved. Always consider ACD to lip balms, facial cosmetics, toothpaste and other oral products, artificial nails, things held in mouth (e.g. metal tool, paperclip), and black hair dye for mustaches. Rarely, consider a consort dermatitis (girlfriend's lip products) causing lip dermatitis. Food may cause ACD of the lips, e.g. eating mangoes. When patch testing is done, nickel and fragrance are the most common offenders.
Irritant Contact Dermatitis
Isotretinoin Cheilitis. Everyone treated with isotretinoin gets dry, chapped lips.
Vitamin Deficiency. Deficiency of several vitamins has been known to cause cheilitis. They include deficiency of zinc, vitamin B2 (riboflavin), vitamin B12 and biotin. Excess of vitamin A may also cause cheilitis.
Rarely, food allergy may cause swollen lips.
Factitial cheilitis may rarely occur.
Mycoplasma Pneumoniae-induced Rash and Mucositis
Toxic Epidermal Necrolysis
Pemphigus Vulgaris PV may present just on the lower lip. For a picture, see Case Reports in Dermatological Medicine Volume 2014 (2014), Article ID 147197,
Cleft lip may occur along with other congenital malformations and in conjunction with various rare cutaneous disorders, e.g., AEC syndrome. A blue macule may rarely be associated, usually in a Japanese child, especially when the cleft goes beyond the vermilion border [JAAD 1994;30].
Angioedema, in this case from the sun, so called solar angioedema.
Ascher Syndrome For a picture, see DermatologicaSinica March 2015;33, Issue 1, Pages 26–28.
Congenital Double Lip For a picture, see Eur J Gen Dent 2014;3:199-201.
Food Allergy: Allergies to food can rarely cause swelling of the lips.
Orofacial Granulomatosis and Melkersson-Rosenthal Syndrome (photo courtesy Michael O. Murphy, MD)
Reaction to injection of filler substance.
Fissured Lip For a picture, see Wikipedia
Squamous Cell Carcinoma
Cancrum Oris For a picture, see Virtual Grand Rounds in Dermatology
Lesch-Nyhan Syndrome: Self-mutilation may occur in Lesh-Nyan Syndrome.
Multiple Mucosal Neuroma Syndrome For a picture, see WeCareIndia
Labial Melanotic Macule
Melanoma For a picture, see JAAD April 2014 Volume 70, Issue 4, Pages 748–762 or Dermatology Online Journal 14(8)
Oral Melanoacanthoma. A rapidly growing solitary brown patch on the oral mucosa [Jama Derm May 2014 150:563]
Postinflammatory Hyperpigmentation This pigmented lesion of several months was biopsy proven to by postinflamatory hyperpigmentation.
Inherited Patterned Lentiginosis in Blacks
Hereditary Hemorrhagic Telangiectasia
Leukoplakia in Actinic Cheilitis
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