Disease Symptoms
Atopic Eruption of Pregnancy Nonspecific eczema and prurigo like lesions.
Polymorphic Eruption of Pregnancy (PUPPP) Urticarial stretch marks
Pruritic Folliculitis of Pregnancy Sterile folliculitis in pregnancy of unknown cause.
Prurigo of pregnancy Excoriated nodules on the trunk and limbs.
Pemphigoid Gestationis Urticarial plaques, vesicles and bulla
Cholestasis of Pregnancy Pruritus with elevated LFTs and serum bile acids

Polymorphic Eruption of Pregnancy (PUPPP)
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Pemphigoid Gestationis
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Physiologic Changes

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Linea nigra
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Autoimmune diseases commonly present during pregnancy due to the immunosuppression required to maintain fetal life.

TH1 cell-mediated immunity decreases: External genital warts may worsen.

Pregnancy and Melanoma

Studies are conflicting with regard to pregnancy and melanoma. Many studies have found that pregnancy-associated melanoma does not have any higher mortality than non-pregnancy related melanoma [JAAD 2014;71;1093]. One study however found the exact opposite [JAAD 2016;74;731]. Of the 41 patients with a pregnancy-associated melanoma there was a 9-fold increase in recurrence (P < .001), 7-fold increase in metastasis (P = .03) and 5-fold increase in mortality (P = .06). It should be noted that this last study included melanoma diagnosed during pregnancy and up to 1 year post partum. Yet, a most recent JAAD CME article stated that "the preponderance of evidence does not support a poorer prognosis for pregnancy-associated melanomas" [JAAD 2016;75;669].

Pregnancy and Nevi

It used to be thought that moles increased in size and darkness during pregnancy. While it is true that moles of the breasts and abdomen may increase in size with normal skin expansion, moles elsewhere do not. Also, recent studies have not been able to document the darkening of moles during pregnancy [JAAD 2016;75;661].


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