POROKERATOSIS TYPES (or Lesions with Ridges)
By Gary M. White, MD
Porokeratosis is a keratinizing disorder characterized by spreading round atrophic rings with a raised ridge as a border corresponding histologically to the cornoid lamella.
- Various genetic mutations have been identified including mevalonate kinase, mevalonate decarboxylase, farnesyl diphosphate synthetase, and phosphomevalonate kinase.
Clinical Variants of Porokeratosis
Disseminated Superficial Actinic Porokeratosis
Eruptive Disseminated Porokeratosis
Giant Porokeratosis: Large atrophic lesions with a ridged border and spanning 10-20 cm in diameter are characteristic. There is a risk of malignant change (e.g., Bowen's disease [Derm 1994;189;782]). [HT 1990;41;633].
Porokeratosis Palmaris Plantaris et Disseminata
Porokeratosis of Mibelli
Genital Porokeratosis (involves the penis, scrotum, or vulvar areas)
Porokeratosis ptychotropica (porokeratosis of the perianal and gluteal regions) [JAMA Derm 2014;150;1007].
86-year-old man with a verrucous form from Acta Dermato-Venereologica 2015;95;241
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