By Gary M. White, MD

There are many, many lesions, both benign and malignant, that can present as a chronic solitary papule. (Let us loosely define the term chronic here as lasting longer than 2 months.) If there is any question about the diagnosis, a biopsy should be taken.

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Basal Cell Carcinoma
Chondroid Syringoma
Cutaneous Focal Mucinosis
Eccrine Spiradenoma
Inverted Follicular Keratosis
Melanoma, Amelanotic
Reticulohistiocytoma, Solitary Type
Sclerotic Fibroma
Sebaceous Adenoma
Syringoma Rarely, a solitary, pearly lesion, at times with a rolled border may prove to be a solitary syringoma.


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