Workup may include: skin biopsy deep enough to sample the subcutaneous fat, CBC, u.a., ASO, throat culture, PPD, CXR, Yersinia titers, liver enzymes, stool culture if diarrhea is present, intradermal or serologic tests for deep fungi, pancreatic enzymes, (e.g. lipase amylase and trypsin), muscle enzymes (dermatomyositis) and alpha-1 antitrypsin level.


Erythema nodosum
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Alpha 1 Antitrypsin Deficiency Panniculitis: Suspect this in the setting of recurrent ulcerative subcutaneous nodules with serosanguinous drainage, lesions primarily on the trunk and proximal extremities; and systemic findings of shortness of breath or limb swelling.

Cold panniculitis For a picture, see Dermatology Online Journal 21(1)

Cytophagic Histiocytic Panniculitis

Dermatomyositis. Dermatomyositis may cause a lobular panniculitis [Clin and Exp Derm 2013;38;443]. Checking muscle enzymes initially and periodically in cases of unexplained lobular panniculitis is in order.

Histoplasmosis AD 121;915

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Lupus panniculitis Deep-seated nodules on the upper outer arm.
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Neutrophilic panniculitis associated with myelodysplastic syndromes (BJD 1997;136;142)

Erythema Induratum/Nodular vasculitis
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Pancreatic panniculitis For a picture, see CMAJ

Subcutaneous T Cell Lymphoma For a picture, see JAAD June 2011 Volume 64, Issue 6, Pages e121–e123

Vilanova disease
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Cold panniculitis For a picture, see Created through inspiration

Subcutaneous fat necrosis of the newborn For a picture, see Dermatology Online Journal 16(2)


Pseudomonas [JAMADerm June 2014]

Trauma can induce panniculitis rarely. This patient developed deep seated nodules that later became neurotic after slamming her leg into a rock.
Traumatic Panniculitis Traumatic Panniculitis


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