By Gary M. White, MD

porokeratosis of Mibelli

The porokeratosis of Mibelli (PM) is the solitary form of porokeratosis.


A small, brownish, hyperkeratotic papule which slowly enlarges to form a serpiginous circular hyperkeratotic ridge with a central atrophic zone is characteristic. PM may occur anywhere. Squamous cell carcinoma, basal cell carcinoma, and Bowen's disease have been reported to develop.

Recommendations on Biopsy

In order to best help the pathologist visualize the cornoid lamella, the following is recommended [Cutis 2016;97;188]:


Cryotherapy, CD, 5-FU occluded, the CO2 laser, or surgical excision may be tried. Dermabrasion has been used successfully.

A PM on the face cleared with two courses of ingenol mebutate 0.015% topical gel applied once daily for 3 consecutive days, with the courses separated by 1 month [JAMA Derm 2015;151;85].

A large PM cleared with 5-FU BID x12 weeks.

Additional Pictures

porokeratosis of Mibelli porokeratosis of Mibelli

Solitary, incipient lesion on the shin of a transplant patient.
porokeratosis of Mibelli

Two lesions on the leg.
porokeratosis of Mibelli

A rather inflamed lesion.
Porokeratosis of Mibelli--inflamed throughout

Porokeratosis of Mibelli of the finger.
Porokeratosis of Mibelli of the finger


Indian J Dermatol Venereol Leprol 2009;75:552-3.

Classic porokeratosis of Mibelli of the palm. Indian Dermatol Online J 2014;5, Suppl S2:130-1


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