Discrete brown to skin-colored keratotic, follicular papules with a central keratinous plug are characteristic. The elbows, extensor side extremities, and buttocks are most common. The changes are usually bilateral, symmetric, and usually asymptomatic. Occasionally there is a mild itch.


A study from South India had showed that the intramuscular injection of Vitamin A/Vitamin B complex are effective in the treatment of phrynoderma [Therapeutic response of Vitamin A, Vitamin B complex, essential fatty acids (EFA) and Vitamin E in the treatment of phrynoderma: A randomized controlled study. J Clin Diagn Res 2014;8:116-8]. In another, the combination therapy with Vitamin A and B along with EFA (Safflower oil) supplementation showed the better results when compared with Vitamin A or B monotherapy [Indian J Paediatr Dermatol 2016;17:108-11].


Indian J Dermatol 2011;56:389-92

Washington University


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