PEMPHIGUS VULGARIS, NEONATAL

Clinical

A neonate with bullae, erosions, or vesicles born to a mom with pemphigus vulgaris either active or in remission is characteristic. For diagnosis, check the DIF of the patient and IIF of the mom. Still birth may occur. Maternal IIF titer less than or equal to 1:80 had a better prognosis in one report [JAAD 1993;29;48].

Treatment

Local wound care may be all that is needed until the disease spontaneously remits. Topical emollients, topical steroids, and antibiotics to prevent/treat infection may be needed.

In a pregnant woman with pemphigus, keeping the antibody titer as low as possible is recommended. Prednisone and IVIG [J Eur Acad Dermatol Venerol 2011;25;1073-9] have both been used for the pregnant mother.

References

JAMA Derm 2014;150;1223 (CP)


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