By Gary M. White, MD

Infection by the parechovirus causes a unique maculopapular rash predominantly of the legs with solid erythema of the soles. It classically can cause sepsis-like syndrome and meningoencephalitis in neonates and young infants.


In a review of cases of infection by human parechovirus type 3 (HPeV3) in young children [Pediatr Infect Dis J. 2013 Mar;32(3):233-6], fever was present in 80%, and the mean age was 33 days. Sepsis-like symptoms, meningoencephalitis, and cardiac instability were seen and 1/3 of the patients required admission to an ICU. All patients developed a rash with onset approximately 3 days after the onset of the fever. Eighty percent of the patients had a very distinctive palmar-plantar erythema, which lasted approximately 3 days.


Pediatr Dermatol. 2014 Mar-Apr;31(2):258-9
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