By Gary M. White, MD
A paraneoplastic syndrome is a set of signs and/or symptoms that result from a malignancy but are not due to the local presence of cancer cells.
- Classic paraneoplastic cutaneous conditions include dermatomyositis, erythema gyratum repens, necrolytic migratory erythema and Sweet's syndrome.
- At least 18 cases of paraneoplastic SCLE have been reported. The most common associated malignancies are lung and breast carcinomas.
- Leukocytoclastic vasculitis is occasionally reported in association with malignancy, particularly solid organ tumors.
- Malignancies constitute 1% of known causative factors for paraneoplastic erythroderma. The most common of them are laryngeal, esophageal, or gastric, or those involving thyroid, lung, gallbladder, colon, fallopian tube, prostate, and lymphomas.
- Less common cutaneous findings, e.g., those in case reports, include papulosquamous, erythematous, and bullous skin lesions.
Proposed Diagnostic Criteria
- Concurrent onset of dermatosis and malignancy.
- Parallel course, where treating one leads to resolution of the other.
- A statistically significant association between certain skin findings and a given malignancy.
- Genetic association between malignancy and skin findings.
Paraneoplastic Annular Rash with Anaplastic Large Cell Lymphoma. Dermatopathology (Basel). 2016 Apr-Jun; 3(2): 39–43.
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