ADULT-ONSET ORBITAL XANTHOGRANULOMA
By Gary M. White, MD
Adult-onset orbital xanthogranuloma (AOOX) is the rare occurrence of xanthogranulomas about the eyes in an adult.
- It falls under the non-Langerhans histocytic disorders.
- Complete history and clinical examination, biopsy and laboratory work is necessary to rule out necrobitoic xanthogranuloma, Erdheim-Chester disease and adult onset asthma with periocular xanthogranuloma. See here for more.
Multiple, firm, non-tender, yellowish-to-red nodules about the eyes of an adult are characteristic of this rare disorder. Histopathology shows a xanthogranuloma. Perhaps a more appropriate name would be periorbital xanthogranulomas.
Surgical excision may be performed.
- Multiple periorbital fibrous histiocytomas. A possible variant of multiple xanthogranulomas., Int J Dermatol. 1991 Dec;30(12):876-8
- Arch Dermatol 1978;114;1345
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