Nodular colloid degeneration (NCD) is an extremely rare cutaneous deposition disorder in which nodular lesions develop over chronically sun-exposed regions. Colloid material deposits in the upper dermis causing the disorder.


Red to purple nodules develop over the nose, forehead, cheeks, or upper chest. Most patients are 40 years or older.


No treatment is needed. Sun protection should be recommended. Surgical excision or laser ablation may be considered.


Case 1: A 48-year-old man with bilateral nodules over the nasal ala for several years. Case 2: A 54-year-old woman with a purple plaque over the right nostril and a round nodule over the nose for two years. Case 3: A 55-year-old woman with an asymptomatic purple plaque over the right cheek with overlying translucent papules. Nodular colloid degeneration of the skin: Report of three cases with review and update. Indian Dermatol Online J 2014;5, Suppl S1:36-9

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