Niacinamide, also known as vitamin B3 or nicotinamide, is a supplement that is sometimes recommended in dermatology. Deficiency of niacinamide causes pellagra.

Niacinamide to prevent BCC and SCC

A placebo-controlled N Engl J Med. 2015 Oct 22;373(17):1618-26 of 386 patients who had been diagnosed with at least two skin cancers - such as basal cell carcinoma and squamous cell carcinoma - in the past five years, showed that taking 500 milligrams twice daily of nicotinamide (not nicotinic acid) reduced the subsequent risk of non-melanoma skin cancers by 23% (20% less BCC, 30% SCC). When patients stopped taking the supplements, their risk of getting skin cancer rose again about six months later. There were very little to no side effects.


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