NEVUS WITH SITE-SPECIFIC ATYPIA
By Gary M. White, MD
Nevi in certain locations tend to have repeatable histologic features. For example, nevi in flexural areas tend to show large nests, large melanocytes, and abundant melanin. Nevi in the groin are similar but the cells often show a slight pagetoid spread. Histologically, moles of the breast tend to exhibit epithelioid melanocytes, slight pagetoid spread, and variable asymmetry. In some cases, these features may simulate melanoma and it may be advisable to completely excise the lesion. However, in most cases, excision is not warranted.
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