By Gary M. White, MD

Neutrophilic eccrine hidradenitis (NEH) is a cutaneous eruption induced by chemotherapy. Histologically, a neutrophilic infiltrate around the eccrine coils is seen.


Two to 21 days after initiation of chemotherapy, erythematous to violaceous papules and/or plaques develop. Annular, macular, and purpuric lesions have also been reported. The lesions are distributed symmetrically affecting axillae, groin, side aspects of the neck, and, to a lesser extent, lower eyelids and inframammary folds.


The lesions usually spontaneously resolve within 10 days.


A 37-year-old woman being treated with cytarabine for AML developed fever and symmetric, erythematous plaques about the eyes and the left breast. Dermatology Online Journal 19(9)

A 58 year-old man 12 days into chemotherapy for AML (cytarabine and idarubicin) developed a diffuse erythematous eruption. [Case Rep Dermatol. 2013 Sep-Dec; 5(3): 340–346]


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