The neurothekeoma is a benign tumor believed to be of nerve sheath origin. Histologically, two variants are seen. The myxoid type shows loosely arrayed spindle cells in a mucinous matrix. The cellular type shows a densely cellular region with epithelioid-appearing cells. The cellular variant may be confused with melanoma. S100 is negative in the cellular variant, distinguishing the two. The myxoid variant is S100 positive.


A solitary, flesh-colored papule is characteristic. It is more common in females in the second or third decade of life. Involvement of the face and upper extremities is common.


Simple excision may be performed.

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