By Gary M. White, MD

Mycoplasma pneumoniae-induced rash and mucositis is a characteristic syndrome caused by infection from Mycoplasma pneumoniae. There is prominent mucositis, most commonly oral, then ocular, then genital. There are less prominent skin changes. For example, patients may have a sparse vesiculobullous eruption. Some have called this atypical Stevens-Johnson syndrome [Pediatrics 2015;136;e386-e394].


In the initial report [JAAD 2015;72:239-45], the average age was 12 years and 2/3 were boys. Oral mucositis was the most common finding (94%). Ocular findings, e.g., purulent bilateral conjunctivitis was present in 82%. Urogenital lesions were found in 62% of cases. Fever, malaise, and cough preceded the eruption by about a week. When skin lesions did occur, vesicobulla were most common, followed by targetoid lesions and less commonly papules, plaques, and transient morbilliform eruptions.


Treatment by a non-dermatologist is necessary. Approximately 1/4 require admission to an intensive care unit.


PD 2017;34;465 JAAD 2015;72:239-45


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