MYCOPHENOLATE MOFETIL

By Gary M. White, MD


Note, this is a brief summary only of mycophenolate mofetil (MM) and is meant to emphasize dermatologic aspects. MM is used much more widely for transplant patients. More complete information and recent studies should be consulted before prescribing MM.

Mechanism of Action

MM inhibits and suppresses lymphocytes. MM is an ester of mycophenolic acid and is currently used to prevent transplant rejection. It is a non-competitive inhibitor of inosine-monophosphate-dehydrogenase and thus influences the function of lymphocytes via the inhibition of purine synthesis. It reversibly blocks the synthesis of guanine nucleotides required for DNA and RNA synthesis during T and B cell proliferation.

Dosing in Dermatology

Common Side Effects

Pregnancy Category D

MM can cause great harm to the developing fetus. MM should not be used in pregnancy.

Indications

Monitoring

Baseline and routine CBC and SGPT are in order. The patient should be questioned among other things about nausea, vomiting, and any signs of infection.

RegionalDerm

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