MELANOMA-ASSOCIATED LEUKODERMA (VITILIGO)
By Gary M. White, MD
These white patches appeared 4 months after diagnosis of this woman's melanoma.
Melanoma-associated leukoderma (MAL) is the concurrent development of vitiligo-like lesions along with melanoma.
- One group defined MAL as the development of depigmented patches within one year of the detection of a primary melanoma, or within three years of the detection of melanoma metastasis with an unknown primary tumor [BJD 2016 Jun 7th]. This group reported seven patients aged 45-72 years.
- A panel of experts could not distinguish MAL from vitiligo [JAAD 2016;75;1198].
The most common pattern was multiple, round, patchy, confetti-like depigmented macules measuring 4-5 mm scattered symmetrically on the trunk, extremities, and/or face.
Treatment of the melanoma is paramount. If an adult presents with "vitiligo" with this pattern, a complete search for melanoma should be undertaken. In the above series, the MAL was resistant to topical steroids and UVB phototherapy.
Same woman as above. MAV appearing in a woman 4 months after diagnosis of the melanoma.
A man with MAV.
A 53-year-old woman presented with well-defined white patches distributed on the cheeks, chin, neck, and sternal area for four months. A complete examination disclosed a melanoma on her right leg. [Dermatology Online Journal 17(1)]
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