By Gary M. White, MD

Marshall's syndrome (MS) is an acquired form of cutis laxa without systemic involvement in which multiple erythematous papules and plaques appear first and upon resolution, leave wrinkled skin in their place.

Note: There is another disease, PFAPA (periodic fever, aphthous stomatitis, pharyngitis, cervical adenitis) syndrome, with the same eponym.


A previously healthy infant develops multiple, firm, inflammatory plaques often accompanied by a fever. These lesions last 1-2 weeks and as the inflammation fades, the skin is left with decreased elasticity, laxity and usually mild atrophy. Multiple episodes may occur over months. The face and neck are most commonly affected. A senile or aged facial expression may result.


A 4-year-old boy with recurrent episodes over 8 months of diffuse, multiple, tender, and well-defined erythematous, edematous plaques. Some plaques had a shiny, wrinkled surface. Indian J Paediatr Dermatol 2016;17:68-70

A 6-year-old boy with infiltrated, well circumscribed erythematous and edematous plaques with polycyclic configuration, on his face, back and extremities for two months, associated with episodes of fever. An Bras Dermatol. 2013;88(2):279-82


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