By Gary M. White, MD

A lupus-like syndrome may be induced by medications. Common drugs capable of inducing a lupus-like syndrome include: Hydralazine, procainamide, isoniazid, phenytoin, thiazide diuretics and beta adrenergic blocking agents. Some of the drugs, e.g. hydralazine, induce antihistone antibodies producing a homogenous pattern.


Several patients have been reported to have findings identical clinically and lab-wise to SCLE but seemingly induced by a drug: Thiazides, griseofulvin, proton pump inhibitors (e.g. omeprazole), calcium channel blockers (e.g. diltiazem, verapamil, nifedipine), mitotane, pyrimidine analogue drugs (fluorouracil, capecitabine, and gemcitabine), mitoses inhibitors (docetaxel, paclitaxel), anthracyclines (doxorubicin with cyclophosphamide) and angiotensin-converting enzyme inhibitors (e.g. captopril, cilazapril). Mean time from starting the drug to disease onset is 4-6 months. See also subacute cutaneous lupus erythematosis.


Letter: Lamotrigine-induced subacute cutaneous lupus erythematous Dermatology Online Journal 18(8)


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