By Gary M. White, MD

Loricrin keratoderma (LK) is a rare autosomal dominant genodermatosis characterized by palmoplantar keratoderma and ichthyosis.


A 14‐year‐old boy presented with generalized dryness and scaling affecting his trunk and all four limbs, previously thought to be ichthyosis vulgaris, which was reported from early childhood examination revealed widespread, prominent ichthyosis and mild diffuse transgredient hyperkeratosis of palms and soles. His mother and eight other family members were similarly affected. Br J Dermatol. 2015 Nov;173(5):1291-4

Palmar honeycomb pattern of keratoderma. JAAD October 2010 Volume 63, Issue 4, Pages 607–641


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