By Gary M. White, MD

cutaneous leiomyosarcoma A very large leiomyosarcoma.

Leiomyosarcoma is a soft-tissue sarcoma. Cutaneous leiomyosarcoma may originate from either the arrector pili muscles, or from the vascular smooth muscles of the subcutaneous adipose tissue.


The leiomyosarcoma most commonly presents as a painful nodule, usually of the extremities (e.g. thigh) in a patient over 50. Men are more frequently affected. Recurrence and metastasis occur. Tumor extension into the subcutis confers a worse prognosis.


Wide local excision and Mohs surgery are the options. Close clinical followup for at least 5-10 years after diagnosis and treatment is recommended.


Recurrent cutaneous leiomyosarcoma of the inner thigh. Indian J Dermatol Venereol Leprol 2015;81:309-11


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