By Gary M. White, MD

The large cell acanthoma is a benign grown defined histologically by the presence of keratinocytes that are about twice normal size (thus, the name).


The large cell acanthoma is a sharply defined plaque most common on the head or arms, but may occur almost anywhere. Most lesions are brown or tan, but they can be flesh-colored or white. Most patients are elderly. There is no sex predilection.


The lesion is benign. Liquid nitrogen is usually effective if treatment is needed.


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