By Gary M. White, MD

Klinefelter syndrome is found in 1 out of 500 males and results from an extra X chromosome (XXY karyotype). Peripheral vascular disease, stasis and leg ulcers are found in patients with Klinefelter syndrome. Some patients have had leg ulcers without signs of venous insufficiency or obesity. Rarely, recurrent leg ulceration in a young man may be the initial manifestation.


Leg Ulcers Associated with Positive Lupus Anticoagulant in Two Cases of Klinefelter’s Syndrome Acta Dermato-Venereologica 2011;91;90-1


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