By Gary M. White, MD
Note: this is only a very, very brief summary and other sources of information should be consulted.
IVIg was approved by the FDA for primary immune deficiency in 1952. It consists of plasma pool of thousands of donors. In therapy for pemphigus, it is thought that these immunoglobulins neutralize and slow down the production of circulating pemphigus antibodies. IVIG is given as an infusion over 3-4 days monthly.
- IVIG is used in dermatology for the treatment of autoimmune bullous disorders, primarily pemphigus and bullous pemphigoid.
- Anaphylactoid reactions can occur in patients deficient in IgA.
There is an eczematous reaction that can occur [JamaDerm Oct 2014;150;1120].
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