ITRACONAZOLE

By Gary M. White, MD

This is only a parietal summary. For this and any other medication, the complete package insert should be consulted.

Indications

CONTRAINDICATIONS

History of heart failure or evidence of left ventricular cardiac dysfunction. Itraconazole can rarely cause congestive heart failure.

DRUG INTERACTIONS

There are significant drug interactions that can lead to QT prolongation and ventricular tachyarrhythmias including torsades de pointes, a potentially fatal arrhythmia.

Dosing for Onychomycosis

Dosing for tinea corporis

SIDE EFFECTS

Nausea and Vomiting

Heart Failure

Itraconazole very rarely can cause congestive heart failure [Indian J Pharmacol. 2013 Sep-Oct; 45(5): 524–525.]

Hepatotoxicity

Rare cases of serious hepatotoxicity, including liver failure and death have been observed. Patients should be screened for any history of liver disease and LFTs measured.

Hearing Loss

Transient or permanent hearing loss has been reported in patients receiving treatment with itraconazole.

Hypokalemia

RARE SIDE EFFECTS

Visual Hallucinations: VH occurred repeatedly in one patient after just 200 mg of itraconazole (Clin Infect Dis 1995;21;456).


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