INTRAVASCULAR PAPILLARY ENDOTHELIAL HYPERPLASIA
By Gary M. White, MD
This subcutaneous blood clot attached to a vessel is the classic location for IPEH.
Intravascular papillary endothelial hyperplasia (IPEH), also known as Masson tumor, is a benign, reactive lesion which is diagnosed histologically. Papillary or tuft-like proliferations of reactive endothelial cells are seen.
- It seems to form in a blood vessel after a thrombus has formed.
It usually presents as a firm, blue-black, dermal or subcutaneous nodule. Occasionally, nodules appear red, mimicking a hemangioma or pyogenic granuloma. It is usually < 2 cm in diameter and red, blue or even black in color. It may be tender or asymptomatic. It commonly occurs on the fingers, head and neck of a middle-aged adult.
Surgical excision both establishes the diagnosis and removes the lesion. Recurrence may occur, especially if there is an associated underlying vascular lesion.
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