By Gary M. White, MD

Indeterminate cell histiocytosis (ICH) is a rare disorder that has histologic features of both Langerhans cell histiocytosis (LCH) and non-LCH. Some have suggested that most patients with ICH actually have a variant of another type of non-LCH, e.g., reticulohistiocytosis, reticulohistiocytoma, benign cephalic histiocytosis, or juvenile xanthogranuloma.


A variety of presentations have been reported including disseminated multiple skin-colored, red, or reddish brown nodules [JAAD 2010;63;e3–e5] and multiple papules on the face mimicking benign cephalic histiocytosis [Dermatology Online Journal].


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