By Gary M. White, MD

IgG4-related disease is characterized by fibroinflammatory lesions and tissue infiltration of IgG4+ plasma cells. High levels of circulating IgG4 are observed in some cases, but not all.


All patients have pruritus. In some cases, cutaneous nodules form. Frequently, IgG4-related disease involves skin lesions that appear as nonspecific patches, plaques, or papulonodules, or as palpable swelling.


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